Pyruvate Dehydrogenase Complex

Detection of anti-M2 autoantibody using recombinant pyruvate dehydrogenase complex E2 and its clinical significance

用重组丙酮酸脱氢酶复合物E2亚单位检测M2抗体及其临床意义

Glucose oxidation via pyruvate dehydrogenase complex did not compensate for reduced palmitate oxidation rates .

通过丙酮酸脱氢酶复合物进行的葡萄糖氧化没有补偿棕榈酸酯氧化率的减少。

Especially new progresses in research of inhibitors of pyruvate dehydrogenase complex were introduced mainly .

主要介绍了具有除草活性好的丙酮酸脱氢酶抑制剂研究新进展。

Regulation of the Activity of the Mammalian Pyruvate Dehydrogenase Complex

哺乳动物中丙酮酸脱氢酶复合体的活性调节

Cloning and expressing the E_2 subunit of pyruvate dehydrogenase complex

丙酮酸脱氢酶复合物E2亚单位的克隆表达与临床应用

Disorders of pyruvate dehydrogenase complex deficiency

丙酮酸脱氢酶复合物缺陷与疾病

Objective To construct the expression vector of the pyruvate dehydrogenase complex E2 subunit gene ( PDC-E2 ) .

目的构建丙酮酸脱氢酶复合物的E2亚单位（PDC-E2）的表达载体。

But2,6-DCPIP cant be used for measuring activity of pyruvate dehydrogenase complex , whereas CoA method is suitable with good sensitivity .

但2，6-二氯吲哚酚法不能用于测定丙酮酸脱氢酶复合体活性，这时用辅酶A法较好，其灵敏度也比较高。

Objective To detect anti-M2 autoantibody using recombinant pyruvate dehydrogenase complex E2 ( PDC-E2 ) in order to help diagnosis of primary biliary cirrhosis ( PBC ) .

目的用重组表达的丙酮酸脱氢酶复合物E2亚单位（PDC-E2）检测M2抗体，以利于原发性胆汁性肝硬化（PBC）的早期诊断。

AMA in PBC are directed to the three ketoacid dehydrogenase complexes , and predominantly to E2 subunit of pyruvate dehydrogenase complex ( PDC-E2 ) .

PBC特异的AMA主要针对位于线粒体内膜的三个酮酸脱氢酶复合物家族（OADC）中的各个亚单位，即线粒体M2抗原的主要成分，其中最主要针对丙酮酸脱氢酶复合物E2亚单位（PDC-E2）。

Objective To develop an ELISA Kit by using prokaryotic expressed products for screening the autoantibodies to binding protein of E2 and E3 subunits ( E2BP and E3BP ) of pyruvate dehydrogenase complex ( PDC ) in the primary biliary cirrhosis ( PBC ) patients .

目的用重组丙酮酸脱氢酶复合物E2亚单位和E3结合蛋白（PDCE2，PDCE3BP）建立筛查原发性胆汁性肝硬化（PBC）患者相应自身抗体的ELISA。

The deficiency of pyruvate oxidase did not cause the obvious accumulation of pyruvate , which indicated that under aerobic condition , the pyruvate metabolism mainly depends on the pyruvate dehydrogenase complex , and pyruvate oxidase does not play the key role .

丙酮酸氧化酶的缺失并没有导致显著的丙酮酸积累，从这一点我们可以看出，有氧条件下丙酮酸的代谢主要依赖于丙酮酸脱氢酶复合体，而丙酮酸氧化酶并不起决定作用。

The activity of pyruvate carboxylase was increased as much as 40 % when the medium was supplemented with Ca 2 + . On the other hand , the activity of the pyruvate dehydrogenase complex was unaffected by the presence of Ca 2 + .

当有Ca2+存在时，胞内丙酮酸羧化酶的活性最高可提高40%，而丙酮酸脱氢酶系的活性没有明显变化。